Publications

1. Zlatic, S.A., Werner, A., Surapaneni, V., Lee, C. E., Gokhale, A., Singleton, K., Duong, D., Crocker, A., Gentile, A., Middleton, F., Dalloul, J. M., Liu, W., Patgiri, A., Tarquinio, D., Carpenter, R., Faundez, V. “Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants” Human Molecular Genetics, (2023) (Patgiri lab co-authors underlined)

2. Zlatic, S.A., Werner, A., Surapaneni, V., Lee, C. E., Gokhale, A., Singleton, K., Duong, D., Crocker, A., Gentile, A., Middleton, F., Dalloul, J. M., Liu, W., Patgiri, A., Tarquinio, D., Carpenter, R., Faundez, V. “Systemic Metabolic and Mitochondrial Defects in Rett Syndrome Models” bioRxiv (2023) (Patgiri lab co-authors underlined)

3. Bulow P, Patgiri A, Faundez V “Mitochondrial Protein Synthesis and the Bioenergetic Cost of Neurodevelopment” iScience (2022) 25(9):104920 (Review)

4. Rath S*, Sharma R*, Gupta R*, Ast T, Chan C, Durham TJ, Goodman RP, Grabarek Z, Hass ME, Hung WHW, Joshi PR, Jourdain AA, Kim SH, Kotrys AV, Lam SS, CCoy JG, Meisel JD, Miranda M, Panda A, Patgiri A, Rogers, Sandre S, Shah H, Skinner OS, To TL, Walker MA, Wang H, Ward PS, Wengrod J, Yuan CC, Calvo SE, Mootha VK “MitoCarta3.0: An updated mitochondrial proteome now with sub-organelle localization and pathway annotations” Nucleic Acid Research (2021) 49(D1):D1541-D1547. (*co-first authors)

5. Patgiri A, Skinner OS, Miyazaki Y, Schleifer G, Marutani E, Shah H, Sharma R, Goodman RP, To TL, Bao XR, Ichiose F, Zapol WM, and Mootha VK “An engineered enzyme that targets circulating lactate to alleviate intracellular NADH/NAD+ imbalance” Nature Biotechnology (2020) 38 (3), 309-313.

Highlights

“Enzyme engineering to fight mitochondrial diseases” (Nature Metabolism)

“Restoring the balance” (Nature Chemical Biology)

“News and Views” (Journal of Inherited Metabolic Disease)

“Experimental therapy may offer hope for rare genetic disorders” (MedicalXpress)

6. Goodman RP, Markhard AL, Shah H, Sharma R, Skinner OS, Clish CB, Deik A, Patgiri A, Hsu YH, Masia R, Loh HL, Suk S, Goldberger O, Hirschhorn JN, Yellen G, Kim JK, and Mootha VK “Hepatic NADH reductive stress underlies common variation in metabolic traits” Nature (2020) 583 (7814), 122-126.

7. Kawashima SA, Chen Z, Aoi Y, Patgiri A, Kobayashi Y, Nurse P, and Kapoor TM “Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis” Cell (2016) 167 (2), 512-524.

8. Patgiri A*, Joy ST*, and Arora PS “Nucleation effects in peptide foldamers” Journal of the American Chemical Society (2012) 134 (28), 11495-502. (co-first authors)

9. Patgiri A*, Yadav KK*, Arora PS, and Bar-Sagi D “An Orthosteric Inhibitor of the Ras-Sos Interaction” Nature Chemical Biology (2011) 7 (9), 585-587. (co-first authors)

Highlights

“Compound to block signaling of cancer-causing protein developed” (ScienceDaily)

10. Patgiri A, Menzenski MZ, Mahon AB, and Arora PS “Solid Phase Synthesis of Short a-Helices Stabilized by the Hydrogen Bond Surrogate Approach” Nature Protocols (2010) 5 (11), 1857-1865.

11. Patgiri A, Witten MR, and Arora PS “Solid Phase Synthesis of Hydrogen Bond Surrogate Derived a-Helices: Resolving the Case of a Difficult Amide Coupling” Organic and Biomolecular Chemistry (2010) 8 (8), 1773-1776.

12. Patgiri A, Jochim AL, and Arora PS “A Hydrogen Bond Surrogate Approach for Stabilization of Short Peptide Sequences in a-Helical Conformation” Accounts of Chemical Research (2008) 41 (10), 1289-1300. (Review article)

13. Chapman R, Kulp III JL, Patgiri A, Kallenbach NR, Bracken C, and Arora PS “Trapping a Folding Intermediate of the a-Helix: Stabilization of the p-Helix” Biochemistry (2008) 47 (14), 4189-4195. (Accelerated Publication)

Patents

1. Mootha VK, Bao XR, and Patgiri A “Extracellular redox enzyme system to alleviate disease” (2023) US Patent 11,661,586

2. Arora PS, Patgiri A, and Joy ST “Proteolytically Resistant Hydrogen Bond Surrogate Helices” (2016) (US Patent No. 9,376,469)

3. Arora PS, Bar-Sagi D, Patgiri A, and Yadav KK “Hydrogen bond surrogate macrocycle peptides as modulators of Ras” (2015) (US Patent No. 8,987,412)